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KMID : 0371919900030010078
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Journal of Wonju College of Medicine
1990 Volume.3 No. 1 p.78 ~ p.86
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Abstract
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To make a differential point in the diagnosis of follicular neoplasm of thyroid gland, 57 cases of follicular neoplasm of thyroid gland were studied for light microscopic findings and immunohistochemical markers, such as thyroglobulin, lactoferrin and ceruloplamin. Thirty two cases were follicular adenomas, and 25 were follicular carcinomas.
In light microscopic observation, irregularity of capsular thickness as well as capsular and/or vascular invasion were confirmed to be valuable in differentiation of follicular carcinoma. But there was no significance in others including nuclear atypism, mitotic rate, ratio of H6.u¨rthlecells, and solid or trabecular arrangement of tumor cells.
Immunohistochemical staining for thyroglobulin was universally positive to all folliculalr cells and colloid of normal tissue, follicular adenoma and follicular carcinoma. But most of normal tissue and follicular adenoma were negative and all follicular carcinomas were positive for lactoferrin and ceruloplasmin.
In conclusion, we found that; 1) among the light microscopic findings, in addition to capsular and/ or vascular invasion. thickness and regularity of tumor capsule were an another helpful index in differentiation of follicular carcinoma, 2) immunohistochemical demonstration of lactoferrin and ceruloplasmin was a useful but not absolutely valuable method in identifying follicular carcinomas.
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KEYWORD
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